Design Structure Matrix (DSM) is a systems engineering paradigm developed by MIT and others to deal with complex inter-relationships between system elements. It is used in many industries. A recent Harvard Business Review article described its use.
As well it turns out Kent Beck - of eXterme Programming fame - makes use a DSM tool as well. For me, this is encouraging. The practices found in systems engineering to deal with complexity, chaos of requirements and design, the interdependencies and intradependencies of components (HW and SW) and the visualization of the solutions to these issues are well developed and deployed routinely on projects in a variety of domains.
These tools and approaches are directly applicable to agile projects and the management of agile projects in the enterprise IT world.